2019
August 2019 - Lab moves to Saint Louis University School of Medicine
After 4 wonderful and productive years at Marquette University, our lab has moved to the Saint Louis University School of Medicine at the Doisy Research Center. The view of the St. Louis Arch from the new lab is not shabby either! A big thanks all our friends and colleagues at Marquette for so many awesome memories...
After 4 wonderful and productive years at Marquette University, our lab has moved to the Saint Louis University School of Medicine at the Doisy Research Center. The view of the St. Louis Arch from the new lab is not shabby either! A big thanks all our friends and colleagues at Marquette for so many awesome memories...
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July 2019 - Second R01 Grant Awarded
Our lab has received a second R01 grant from the National Institutes of Health R01GM133967. "Mechanisms of RPA, Recombinases, and Mediators in Homologous Recombination", NIGMS. Congrats to the team ......... |
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June 2019 - Students presented posters and a talk at the Gordon Research Conference in Maine.
Graduate students Nilisha Pokhrel and Sahiti Kuppa along with our undergraduate student Emma Tillison presented posters at the GRC conference. Nilisha also chaired a session at the GRS and gave a talk at the conference. |
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May 2019 - Elliot has received the "Oliver H. Smith Academic Achievement Award" from Marquette University. This award recognizes Elliot for his exceptional academic and research achievement in the Ph.D. program. Congratulations !!
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May 2019 - Nilisha wins a "Best Talk" award at the Midwest DNA Repair Conference.
Nilisha Pokhrel and Sahiti Kuppa presented posters and Nilisha gave a talk at MDRC held at Washington University in Saint Louis. Nilisha won an award for "Best Talk". Congratulations...... Interesting fact: Her PI gave his first formal conference talk at the very same auditorium in 2008. |
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April 2019 - Nilisha receives the Grotelueschen Scholarship.
Congratulations and well deserved. The scholarship supports her research over the summer months in 2019.
Congratulations and well deserved. The scholarship supports her research over the summer months in 2019.
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April 2019 - Emma presented her poster at the Annual AACR Conference in Atlanta as one of their Undergraduate Scholar Awardee.
Her poster was titled "Colonic adenocarcinoma-associated DNA-binding site mutations in Rad52 perturbs its ssDNA binding polarity and function in Homologous Recombination" |
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February 2019 - Edwin receives TENURE at Marquette University
A celebratory February '19 closes with Edwin receiving tenure and being promoted to Associate Professor....
A celebratory February '19 closes with Edwin receiving tenure and being promoted to Associate Professor....
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February 2019 - Edwin gave a talk at the 6th Nucleic Acids Fusion Conference.
The title of his talk was "Re-establishing the roles of the DNA binding domains of RPA and got to hang out with the legends of DNA replication and repair: Steve West, Steve K, John Diffley and David Lilley |
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February 2019 - Elliot has been awarded the Arthur J. Schmitt Leadership Fellowship for 2019-20
Congratulations, and well deserved. More information about this program can be found here: https://www.marquette.edu/grad/finaid-schmitt.php |
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February 2019 - Emma received the 2019-2020 American Association for Cancer Research (AACR) Undergraduate Scholar Award.
The award fully supports Emma to attend and present her work at two consecutive annual AACR national meetings at Atlanta (2019) and San Deigo (2020). Well deserved and congratulations!! |
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February 2019 - New Paper Published and Featured on the Cover
Our work on RPA mechanism, in collaboration with the Spies laboratory (Univ. of Iowa) was published in Nature Structural and Molecular Biology. Congrats Nilisha, Elliot and Emma. |
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January 2019 - New R01 Grant Awarded
Our lab has received a new R01 grant from the National Institutes of Health R01GM130746. "Mechanisms of DNA hand-off during lesion repair in BER and NER", NIGMS and NIEHS. Read about the work: CLICK HERE Congrats to the team ......... |
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2018
December 2018 - New Paper Published
Our work on RPA mechanism, in collaboration with the Zhang laboratory (Imperial College, UK) was published in Nature Communications. Congrats Nilisha!!
Our work on RPA mechanism, in collaboration with the Zhang laboratory (Imperial College, UK) was published in Nature Communications. Congrats Nilisha!!
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November 2018 - Nilisha takes a day off from the bench to do non-significant things.........like getting married!
Congrats to Nilisha and Mark on this wonderful occasion. |
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September 2018 - New paper published.
Our work on the utility of phosphate binding proteins as a phosphate removal tool during water purification, in collaboration with the Mayer lab (Dept of Engineering, Marquette University) was published in Water Research X. Congrats Nilisha!
Our work on the utility of phosphate binding proteins as a phosphate removal tool during water purification, in collaboration with the Mayer lab (Dept of Engineering, Marquette University) was published in Water Research X. Congrats Nilisha!
August 2018 - Three papers published.
We have three new papers published.
The first paper, in collaboration with the Galletto lab at Washington University, describes the mechanism of Rim1 (Singh et al, Nuc. Acids Research).
The second paper is a review article, in collaboration with the Seefeldt group at Utah State, presents a new model for Nitrogenase function (Seefeldt et al Accounts of Chemical Research).
The third paper, in collaboration with the Balci group at Kent State, describes a new tool to correlate Force and Fluorescence measurements in single molecule experiments (Mustafa et al Biosensors and Bioelectronics).
We have three new papers published.
The first paper, in collaboration with the Galletto lab at Washington University, describes the mechanism of Rim1 (Singh et al, Nuc. Acids Research).
The second paper is a review article, in collaboration with the Seefeldt group at Utah State, presents a new model for Nitrogenase function (Seefeldt et al Accounts of Chemical Research).
The third paper, in collaboration with the Balci group at Kent State, describes a new tool to correlate Force and Fluorescence measurements in single molecule experiments (Mustafa et al Biosensors and Bioelectronics).
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August 2018 - NSF MRI Grant Awarded
Our MRI grant was funded by the NSF to build a TIRF microscope at MU paving way for single molecule experiments!! |
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August 2018 - Nilisha, Elliot and Sahiti presented posters at the Genetic Code Expansion Meeting in Oregon.
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May 2018 - Edwin gave a talk at The University of St. Andrews
The title of his talk was: "The ABCDs of RPA-DNA interactions" and was hosted by Dr. Carlos Peneda. He also managed to sneak in a round at the "Old Course" in St. Andrews. |
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May 2018 - Nilisha presented a poster at the Abcam - Mechanism of Recombination 2018 conference in London.
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May 2018 - Nilisha has received the "Oliver H. Smith Academic Achievement Award" from Marquette University. This award recognizes Nilisha for her exceptional academic and research achievement in the Ph.D. program. Congratulations !!
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April 2018 - Emma wins best talk award at MUBRC.
Emma Tillison, an undergraduate researcher in our laboratory was awarded the best talk award at the Milwaukee-area Undergradaute Biological Research Conference held at Wisconsin Lutheran College last weekend. Her talk was titled "Biophysical Insights into Rad52 Mediator Functions" Well done Emma. Congratulations!! |
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March 2018 - Award for Nilisha
Nilisha Pokhrel has been awarded the Dr.Catherine Grotelueschen 2018 Summer Scholarship. Congratulations!!
Nilisha Pokhrel has been awarded the Dr.Catherine Grotelueschen 2018 Summer Scholarship. Congratulations!!
February 2018 - New Students Join the Group
We welcome two new graduate students into our group: Niharika Rajnala and Sahiti Kuppa.
We also welcome two new undergraduate students into our group: Emma Tillison and Bradley Hanson.
Welcome to the group!!
We welcome two new graduate students into our group: Niharika Rajnala and Sahiti Kuppa.
We also welcome two new undergraduate students into our group: Emma Tillison and Bradley Hanson.
Welcome to the group!!
February 2018 - New Grant
Our lab, in collaboration with the Origanti lab (MU) and the Volkman lab (MCW), has received a Marq/MCW-MPI Pilot Grant.
Our lab, in collaboration with the Origanti lab (MU) and the Volkman lab (MCW), has received a Marq/MCW-MPI Pilot Grant.
February 2018 - New Paper
Antony E., and Lohman T.M. Dynamics of E. coli single stranded DNA binding (SSB) protein-DNA complexes. Seminars in Cell and Developmental Biology. In Press.
Antony E., and Lohman T.M. Dynamics of E. coli single stranded DNA binding (SSB) protein-DNA complexes. Seminars in Cell and Developmental Biology. In Press.
February 2018 - Award for Nilisha
Nilisha Pokhrel has been awarded the prestigious Rev. John P. Raynor SJ Graduate Fellowship Award for 2018-2019. Well deserved! Congratulations!!
Nilisha Pokhrel has been awarded the prestigious Rev. John P. Raynor SJ Graduate Fellowship Award for 2018-2019. Well deserved! Congratulations!!
February 2018 - Award for Edwin
Edwin has been awarded the 2018 Way-Klingler Young Scholar Award.
Edwin has been awarded the 2018 Way-Klingler Young Scholar Award.
2017
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October 2017 - Nilisha wins best poster award at MECC 2017
Nilisha, Elliot and Daisy presented posters at the Midwest Enzyme Chemistry Conference and Nilisha won a Best Poster Award at the meeting. Congratulations!! |
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July 2017 - Poster Presentations
Daisy Oceguera and Ayaa Shanaa presented posters detailing their summer research work at Marquette University. Daisy was part of the NSF-REU program at Marquette and Ayaa was a part of the McNair Scholars Program. Great Job!! |
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July 2017 - New Paper
Our paper describing RPA dynamics in HR is accepted for publication in Nucleic Acids Research. Pokhrel, et. al. Monitoring Replication Protein A (RPA) dynamics through site-specific incorporation of non-canonical amino acids. Nucleic Acids Research. 2017. In Press.
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June 2017 - Lab Celebrations
The lab celebrated various milestones. Nilisha and Elliot passed their qualifying exams and are officially 'candidates' towards their PhD. Dr. Origanti has secured her independent tenure track position at Marquette and will be starting her own research group this Fall. Nilisha's paper has been accepted for publication. |
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May 2017 - New Grant
The lab has received a new 3-year grant from the Department of Energy. |
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May 2017 - 19th Annual Midwest DNA Repair Symposium
Nilisha presented a poster at the 19th AMDRS event held at Wright State University, Dayton OH. Her poster was titled: " Context-dependent remodeling of RPA during homologous recombination captured using non-canonical amino acid-based fluorescent RPA."
Nilisha presented a poster at the 19th AMDRS event held at Wright State University, Dayton OH. Her poster was titled: " Context-dependent remodeling of RPA during homologous recombination captured using non-canonical amino acid-based fluorescent RPA."
April 2017 - March for Science
The lab had a fun day representing at the "March for Science"
The lab had a fun day representing at the "March for Science"
January 2017 - 25th Enzyme Mechanisms Conference
Nilisha and Elliot presented posters at the 25th Enzyme Mechanisms Conference in St. Pete's Beach, FL. Edwin chaired the "Founder's Award, Radical Chemistry and More" session at the meeting.
Nilisha and Elliot presented posters at the 25th Enzyme Mechanisms Conference in St. Pete's Beach, FL. Edwin chaired the "Founder's Award, Radical Chemistry and More" session at the meeting.
2016
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November 2016 - Press Release on our work.
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November 2016 - New Graduate Roton
We welcome Niharika Rajnala as a new rotation student in our group..
We welcome Niharika Rajnala as a new rotation student in our group..
October 2016 - Eric Parker Davenport, our former graduate student is hired at AGTC.
(http://www.agtc.com/). We are proud of you. Congratulations!!!!
(http://www.agtc.com/). We are proud of you. Congratulations!!!!
October 2016 - Nitrogenase asymmetry paper published in PNAS
Danyal, K., Shaw, S., Page, T.P., Duval, S., Fielding, A.J., Horitani, M., Marts, A.R., Lukoyanov, L., Dean, D.R., Raugei, S., Hoffman, B.M., Seefeldt, L.C. and Antony E. Negative Cooperativity in the Nitrogenase Fe Protein Electron Delivery Cycle. PNAS. 2016 doi: 10.1073/pnas.161308911
Danyal, K., Shaw, S., Page, T.P., Duval, S., Fielding, A.J., Horitani, M., Marts, A.R., Lukoyanov, L., Dean, D.R., Raugei, S., Hoffman, B.M., Seefeldt, L.C. and Antony E. Negative Cooperativity in the Nitrogenase Fe Protein Electron Delivery Cycle. PNAS. 2016 doi: 10.1073/pnas.161308911
October 2016 - Midwest Enzyme Chemistry Conference
Edwin gave a talk at the 34th MECC conference.
Nilisha Pokhrel and Elliot Corless (graduate students) presented posters at the meeting.
Edwin gave a talk at the 34th MECC conference.
Nilisha Pokhrel and Elliot Corless (graduate students) presented posters at the meeting.
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July 2016 - Parker's Paper is Accepted for Publication
Parker's work on using the SSB protein from Plasmodium falciparum as a tool to monitor Rad51 disassembly by Srs2 has been accepted for publication in PLOS One. Congrats!
Parker's work on using the SSB protein from Plasmodium falciparum as a tool to monitor Rad51 disassembly by Srs2 has been accepted for publication in PLOS One. Congrats!
June 2016 - Nilisha Receives Two Travel Awards
Nilisha Pokhrel, a graduate student in the lab has received two travel awards to attend the "International Genetic Code Expansion Conference and Workshop" at Oregon State University. She received a travel award from the Conference and the Charles O'Hara Scholarship Award from Marquette University. Congrats!
Nilisha Pokhrel, a graduate student in the lab has received two travel awards to attend the "International Genetic Code Expansion Conference and Workshop" at Oregon State University. She received a travel award from the Conference and the Charles O'Hara Scholarship Award from Marquette University. Congrats!
June 2016 - New High School Student
Pratyusha Emkay, a junior high school student from Greenfield High School has joined the lab. Welcome!
Pratyusha Emkay, a junior high school student from Greenfield High School has joined the lab. Welcome!
June 2016 - New Paper Published
Our work with the Seefeldt lab has been published in Biochemistry. The results show that in the presence of Flavodoxin (as the reductant), phosphate release becomes the rate-limiting step in the electron transfer cycle. ang ZY, Ledbetter R, Shaw S, Pence NK, Tokmina-Lukaszewska M, Eilers BJ, Guo Q, Pokhrel N, Cash VL, Dean DR, Antony E, Bothner B, Peters JW, Seefeldt LC. Evidence that the Pi Release Event is the Rate Limiting Step in the Nitrogenase Catalytic Cycle. 2016. In press.
Our work with the Seefeldt lab has been published in Biochemistry. The results show that in the presence of Flavodoxin (as the reductant), phosphate release becomes the rate-limiting step in the electron transfer cycle. ang ZY, Ledbetter R, Shaw S, Pence NK, Tokmina-Lukaszewska M, Eilers BJ, Guo Q, Pokhrel N, Cash VL, Dean DR, Antony E, Bothner B, Peters JW, Seefeldt LC. Evidence that the Pi Release Event is the Rate Limiting Step in the Nitrogenase Catalytic Cycle. 2016. In press.
May 2016 - New Undergraduate Students
Jessica Jungers and Sandeep Buddharaju are juniors at Marquette University and have joined the lab as undergraduate researchers. Welcome.
Jessica Jungers and Sandeep Buddharaju are juniors at Marquette University and have joined the lab as undergraduate researchers. Welcome.
March 2016 - New Graduate Students
Nilisha Pokhrel and Elliot Corless have joined the lab as graduate students. Welcome!
Nilisha Pokhrel and Elliot Corless have joined the lab as graduate students. Welcome!
March 2016 - New Paper Published
Our investigation of the ATPase activity of the type III secretion apparatus motor protein, Spa47, has been accepted for publication in Protein Science. Burgess J., Jones H.B., Kumar P., Toth R., Middaugh C.R., Antony E.* and Dickenson N.E.*. Spa47 is an oligomerization-activated type three secretion system (T3SS) ATPase from Shigella flexneri. Protein Science. In Press. (*Co-Corresponding Authors)
Our investigation of the ATPase activity of the type III secretion apparatus motor protein, Spa47, has been accepted for publication in Protein Science. Burgess J., Jones H.B., Kumar P., Toth R., Middaugh C.R., Antony E.* and Dickenson N.E.*. Spa47 is an oligomerization-activated type three secretion system (T3SS) ATPase from Shigella flexneri. Protein Science. In Press. (*Co-Corresponding Authors)
February 2016 - Students Defend Thesis
Mark Soffe and Parker Davenport, two MS students in our lab, have successfully defended their thesis. Congratulations!
Mark Soffe and Parker Davenport, two MS students in our lab, have successfully defended their thesis. Congratulations!
2015
October 2015 - Teach with SSB Project is Officially Underway
Our laboratory teaching program with the SSB protein as a model system is finally in place. The course material and information can be found at the following website: www.teachwithSSB.com
Our laboratory teaching program with the SSB protein as a model system is finally in place. The course material and information can be found at the following website: www.teachwithSSB.com
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September 2015 - Parker and Elliot Presented Posters
Students from our lab presented posters at the Midwest Enzyme Chemistry Conference held at Chicago. |
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August 2015 - NSF MRI Grant Awarded
Our MRI grant was funded by the NSF to obtain an Analytical Ultracentrifuge (AUC) at USU. It was our Christmas wishlist :) |
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July 2015 - Move to Marquette University
We have now moved to Marquette University located in Milwaukee, Wisconsin.
Our sincere thanks to everybody at Utah State University for supporting our research efforts over the last three years.
We have now moved to Marquette University located in Milwaukee, Wisconsin.
Our sincere thanks to everybody at Utah State University for supporting our research efforts over the last three years.
April 2015 - URCO recommendations
URCO grant proposals for three undergraduate students in our lab - Cason Wortley, Jessica Anderson and Brantley Bond were recommended for funding. Congratulations!
URCO grant proposals for three undergraduate students in our lab - Cason Wortley, Jessica Anderson and Brantley Bond were recommended for funding. Congratulations!
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March 2015 - Graduate Student Receives the Piette Scholarship from USU.
Derek Harris, a graduate student in the lab has been awarded the 2015 Piette Scholarship at Utah State University. Congratulations |
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March 2015 - New NIH Grant Awarded
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February 2015 - Capitol Hill Presentations
Undergraduate students, Elliot Corless and Mark Stoll, presented posters on their research at the 'Utah Research on Capitol Hill" event at Salt Lake City, UT on Jan 29th, 2015. Congratulations!
Undergraduate students, Elliot Corless and Mark Stoll, presented posters on their research at the 'Utah Research on Capitol Hill" event at Salt Lake City, UT on Jan 29th, 2015. Congratulations!
January 2015 - Article about undergraduate student research in our lab on USU Today
Please click here to read the article.
Please click here to read the article.
January 2015 - New Students Join the Group
Derek Harris (graduate student) and Jessica Anderson (undergraduate student) have joined the group. Welcome!
Derek Harris (graduate student) and Jessica Anderson (undergraduate student) have joined the group. Welcome!
January 2015 - New Paper Published
Kozlov A.G., Weiland E., Mittal A., Waldman V., Antony E., Fazio N., Pappu R.V. and Lohman T.M. Intrinsically disordered C-terminal tails of E. coli single stranded DNA binding protein regulate cooperative binding to single stranded DNA. J. Mol. Biol. 2015. In Press
Kozlov A.G., Weiland E., Mittal A., Waldman V., Antony E., Fazio N., Pappu R.V. and Lohman T.M. Intrinsically disordered C-terminal tails of E. coli single stranded DNA binding protein regulate cooperative binding to single stranded DNA. J. Mol. Biol. 2015. In Press
2014
December 2014 - Grant Awarded
The Antony Lab has received a "Research Catalyst" grant from USU to pursue exploration of the Sen1 helicase and its function in transcription termination.
The Antony Lab has received a "Research Catalyst" grant from USU to pursue exploration of the Sen1 helicase and its function in transcription termination.
November 2014 - Five Students Receive URCO Grants
Five undergraduate students from the lab: Dallas Elder, Mat Rasmussen, Elliott Corless, Dan Morris and Mark Stoll have received URCO grants. Please see the Student achievement section for more detail.
Five undergraduate students from the lab: Dallas Elder, Mat Rasmussen, Elliott Corless, Dan Morris and Mark Stoll have received URCO grants. Please see the Student achievement section for more detail.
September 2014 - Students Receive Poster Awards
Jeff, Mark, Parker & Tanner, Matthew, and Tawnie presented their research at the 4th Annual Hansen Departmental Retreat.
Elliot, Mat and Mark Stoll co-presented their SSB-teaching poster.
Parker Davenport won the best poster award for undergraduate students and Matthew Radovan received an honorable mention. Congrats!!
Jeff, Mark, Parker & Tanner, Matthew, and Tawnie presented their research at the 4th Annual Hansen Departmental Retreat.
Elliot, Mat and Mark Stoll co-presented their SSB-teaching poster.
Parker Davenport won the best poster award for undergraduate students and Matthew Radovan received an honorable mention. Congrats!!
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September 2014
Edwin was invited to give a talk at Wesleyan University, Middletown CT during the 15th Annual Wesleyan Molecular Biophysics Program on Sept 18th at the Wadsworth Mansion in Middletown CT. Click here for a press release from the event. |
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July 2014
Matthew Radovan (9th grade student from Logan) joins our research team.
Matthew Radovan (9th grade student from Logan) joins our research team.
July 2014
High school students participate in a week long research camp in our lab.
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June 2014
Edwin presented a poster at the Gordon Research Conference in June, 2014. "Iron-Sulfur Enzymes", Stonehill College, MA
Edwin presented a poster at the Gordon Research Conference in June, 2014. "Iron-Sulfur Enzymes", Stonehill College, MA
April 2014
Mark Soffe was selected to participate in the Utah Conference on Undergraduate research at BYU (Provo) and presented a poster.
Mark Soffe was selected to participate in the Utah Conference on Undergraduate research at BYU (Provo) and presented a poster.
March 2014
Jeff, Mark, Tanner and Danyal presented posters at the USU Research Week
Jeff, Mark, Tanner and Danyal presented posters at the USU Research Week
Jeff Vongermeten presented a poster at the USU research week. Spring 2014
Mark Soffe presented a poster at the USU research week. Spring 2014
Tanner Tripp presented a poster at the USU research week. Spring 2014
March 2014
Edwin presented a poster at the AbCam meeting in March 2014. "Maintenance of Genomic Stability 2014". St. Kitts
Edwin presented a poster at the AbCam meeting in March 2014. "Maintenance of Genomic Stability 2014". St. Kitts
February 2014 - New Paper Published
Our paper on Srs2 activity is published in JMB.
Our paper on Srs2 activity is published in JMB.
February 2014
Mark Soffe presented his poster at the "Research on Capitol Hill" at Salt Lake city. Spring 2014
Mark Soffe presented his poster at the "Research on Capitol Hill" at Salt Lake city. Spring 2014
2013
September 2013
Mark Soffe presented a poster at the 2013 Hansen Life Sciences Retreat and won the best undergraduate poster prize. Congrats Mark!!
Mark Soffe presented a poster at the 2013 Hansen Life Sciences Retreat and won the best undergraduate poster prize. Congrats Mark!!
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August 2013 - New Paper Published
Our nitrogenase paper is published in PNAS.
Our nitrogenase paper is published in PNAS.
February 2013
Jeff Vongermeten presented his poster at the "Research on Capitol Hill" at Salt Lake city. Spring 2013
Jeff Vongermeten presented his poster at the "Research on Capitol Hill" at Salt Lake city. Spring 2013
August 2012
Our first set of pipettes have arrived........"We are officially open and can begin performing experiments"
Our first set of pipettes have arrived........"We are officially open and can begin performing experiments"
