We are looking for talented and driven individuals to join our research team.
Postdoctoral and Staff Positions POSTDOCTORAL POSITIONS IN BIOPHYSICS & STRUCTURAL BIOLOGY OF DNA REPAIR & RECOMBINATION and ELECTRON TRANSFER ENZYMES Multiple postdoctoral positions are available in the lab of Prof. Edwin Antony at Saint Louis University School of Medicine. We are looking for exceptionally driven and motivated researchers who will strive to carry out projects that decipher the molecular underpinnings of enzyme complexes. Three specific postdoctoral positions are available. We will also consider research scientists who have been trained in the specific skillsets detailed under each position. The ideal researcher for the positions will have a strong background in in vitro biochemistry using recombinantly purified protein complexes. For the NIH-funded positions below, experience in either single-molecule biophysics, structural biology (especially cryo-EM microscopy), enzyme kinetics (stopped flow fluorescence), molecular biology and/or biochemistry of protein-nucleic acid interactions will be required. For the DOE-funded position, a strong background in working with proteins in a glove box is required along with experience using EPR and other spectroscopic or bioinorganic tools. Saint Louis University School of Medicine provides ample opportunities for cutting edge, interdisciplinary and collaborative research. In addition, multiple-collaborative opportunities exist with researchers at the neighboring Washington University in St. Louis. Saint Louis City is also a delightful and affordable town to live in and raise a family with free admissions to parks, zoos, and museums. Saint Louis is also one of the fastest growing biotech and biopharmaceutical cities in the USA and filled with career opportunities and thus is an excellent environment for postdoctoral studies (https://www.biospace.com/article/st-louis-one-of-the-fastest-growing-life-sciences-markets/).
Position 1: Molecular and structural basis of RPA function in DNA repair This project is funded by multiple R01 grants from the NIH. We aim to decipher how replication protein A (RPA) functions to recruit DNA-Repair enzymes onto DNA. A wide range of experimental tools are deployed including, cryo-EM, single-molecule microscopy, rapid kinetics, fluorescence using non-canonical amino acids, and hydrogen-deuterium exchange.
Position 2: Single molecule studies of electron transfer in nitrogenase-like enzymes This project is funded by the Department of Energy. We aim to decipher how DPOR (dark operative protochlorophyllide oxidoreductase), a key enzyme in the dark-driven chlorophyll biosynthetic pathway, catalyzes multi-electron substrate reduction reactions. A wide range of experimental tools are deployed including, cryo-EM, single-molecule microscopy, rapid kinetics, fluorescence using non-canonical amino acids, and hydrogen-deuterium exchange. In addition, we use EPR and other bioinorganic tools to investigate the properties of its metal centers.
Candidates interested in the postdoctoral or scientist positions should directly contact Dr. Antony (firstname.lastname@example.org) with a copy of their CV/resume and a cover letter stating why our group would be a good fit.
Research Technicians We are looking for one research technician with extensive experience working with recombinant proteins. The ideal candidate will have purified proteins using E. coli overexpression systems. The ability to express proteins using insect cell systems will be an added bonus. Experience working with standard molecular biology methods (cloning) and biochemical tools (SDS-PAGE gels) is also required. If interested, please contact Dr. Antony.
Graduate Students The Antony group has always served as an exceptional training group for graduate students. Our two most recent graduate students have secured postdoctoral fellowships at MIT and New England Biolabs. Interested students, who have been accepted into the graduate program at SLU can contact Dr. Antony to schedule their rotations. Future graduate students, interested in the graduate program at SLU can find more information here: https://biochem.slu.edu/graduate/
Undergraduate Students Please contact Dr. Antony for research opportunities
High School Summer Students Please contact Dr. Antony for research opportunities