PUBLICATIONS

Publications

Ahmad, F., Patterson, A., Deveryshetty, J., Mattice, J., Pokhrel, N., Bothner, B., and Antony, E. Hydrogen-deuterium exchange reveals a dynamic DNA binding map of Replication Protein A. In Press. Nucleic Acids Research.
Read BioRxiv Preprint. 2020. HERE.

Corless, E.I., Imran S.M.S., Watkins, M.B., Bacik, J.P., Mattice J., Patterson A., Danyal, L.C., Soffe, M., Kitelinger, R., Seefeldt L.C., Origanti, S., Bennett, B., Ando, A., and Antony, E. The flexible N-terminus of BchL autoinhibits activity through interaction with its [4Fe-4S] and relieved upon ATP binding. J. Biol. Chem. 2020. HERE.

Quinn, S.M., Vargason, T., Pokhrel, N., Antony, E., Hahn, J., and Gilbert S.P. KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step. J. Biol. Chem. 2020. doi: 10.1074/jbc.RA120.015272

Corless, E.I., Bennet, B.B., and Antony, E. Substrate recognition induces sequential electron transfer across subunits in the nitrogenase-like DPOR complex. Journal of Biological Chemistry.
J Biol Chem. 2020 Sep 25;295(39):13630-13639. doi: 10.1074/jbc.RA120.015151. LINK.

Corless, E. I., Mettert, E. L., Kiley, P. J. and Antony, E. Elevated Expression of a Functional Suf Pathway in the E.coli BL21(DE3) Cell Line Enhances Recombinant Production of an Iron-Sulfur Cluster Containing Protein. J Bacteriol. 2020 Jan 15;202(3):e00496-19. doi: 10.1128/JB.00496-19. LINK.

Pokhrel N., Caldwell, C.C., Corless, E.I., Tillison, E.A., Tibbs, J., Jocic, N., Ali Tabei, S.M., Wold, M.S., Spies, M. and Antony E. Dynamics and Selective Remodeling of the DNA Binding Domains of RPA. Nature Structural & Molecular Biology. 26, p129–136 (2019).
https://www.nature.com/articles/s41594-018-0181-y
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Yates LA, Aramayo RJ, Pokhrel N, Caldwell CC, Kaplan JA, Perera RL, Spies M, Antony E, and Zhang X. A structural and dynamic model for the assembly of Replication Protein A on single stranded DNA. Nature Communications. 2018. doi: 10.1038/s41467-018-07883-7

Venkiteshwaran K., Pokhrel N., Hussein F., Antony E., and Mayer B.K. Phosphate removal and recovery using phosphate binding proteins. Water Research X. 2018. https://doi.org/10.1016/j.wroa.2018.09.003

Mustafa G., Chuang C. , Roy W.A., Farhath M.A., Pokhrel N., Ma Y., Nagasawa K., Antony E., Comstock M.J., Basu S., and Balci H. A Force Sensor that Converts Fluorescence Signal into Force Measurement Utilizing Short Looped DNA. Biosensors and Bioelectronics. 2018. doi: 10.1016/j.bios.2018.08.073

Seefeldt L., Hoffman B., Peters J., Raugei S., Antony E., and Dean D. Energy Transduction in Nitrogenase. Accounts of Chemical Research. 2018. doi: 10.1021/acs.accounts.8b00112

Singh S.P., Kukshal V., De Bona P., Antony E., and Galletto R. The mitochondrial single-stranded DNA binding protein from S. cerevisiae, Rim1, does not form stable homo-tetramers and binds DNA as a dimer of dimers. Nucleic Acids Research. 2018. doi: 10.1093/nar/gky530

Antony E., and Lohman T.M. Dynamics of E. coli single stranded DNA binding (SSB) protein-DNA complexes. Seminars in Cell and Developmental Biology. 2018. S1084-9521(17)30432-9. DOI: 10.1016/j.semcdb.2018.03.017

Pokhrel N., Origanti S., Davenport E.P., Gandhi D., Kaniecki K., Mehl R., Greene E., Dockdendorff C., and Antony E. Monitoring Replication Protein A (RPA) dynamics through site-specific incorporation of non-canonical amino acids. Nucleic Acids Research. 2017. 45(16):9413-9426. DOI: https://doi.org/10.1093/nar/gkx598

Danyal, K., Shaw, S., Page, T.P., Duval, S., Fielding, A.J., Horitani, M., Marts, A.R., Lukoyanov, L., Dean, D.R., Raugei, S., Hoffman, B.M., Seefeldt, L.C. and Antony E. Negative Cooperativity in the Nitrogenase Fe Protein Electron Delivery Cycle. PNAS. 2016. doi: 10.1073/pnas.1613089113

Press Release 1

Press Release 2

Davenport E.P., Harris D.F., Origanti S., and Antony E. Rad51 nucleoprotein filament disassembly captured using fluorescent Plasmodium falciparum SSB as a reporter for single-stranded DNA. PLos One. 2016.
http://dx.doi.org/10.1371/journal.pone.0159242

Yang Z.Y., Lebbetter R., Shaw S., Pence N., Tokmina-Lukaszewska M., Eilers B., Guo Q., Pokhrel N., Cash V.L., Dean D.R., Antony E., Bothner B., Peters J.W., and Seefeldt L.C. Evidence that the Pi release event is the rate limiting step in the nitrogenase catalytic cycle. Biochemistry. 2016. 5:55(26):3625-3635.

Burgess J., Jones H.B., Kumar P., Toth R., Middaugh C.R., Antony E.* and Dickenson N.E.*. Spa47 is an oligomerization-activated type three secretion system (T3SS) ATPase from Shigella flexneri. Protein Science. 2016. 25(5):1037-48. (*Co-Corresponding Authors)

Duval S., Danyal K., Shaw S., Dean D.R., Hoffman B.M., Antony E*. and Seefeldt L.C.* Establishing the order of electron transfer and ATP hydrolysis in Nitrogenase . PNAS. 2013. 110:16414-16419 (*Co-Corresponding Authors).
Highlighted in Science
USU Press Release

Lytle, A.K., Origanti, S., Vongermeten, G., and Antony E. Context dependent remodeling of Rad51-DNA complexes by Srs2 is mediated by a specific protein-protein interaction. J. Mol. Biol. 2014. 426:1888-1897.

Postdoctoral and Graduate Publications

Kozlov A.G., Weiland E., Mittal A., Waldman V., Antony E., Fazio N., Pappu R.V. and Lohman T.M. Intrinsically disordered C-terminal tails of E. coli single stranded DNA binding protein regulate cooperative binding to single stranded DNA. J. Mol. Biol. 2015. 427:763-774

Antony E., Weiland, E, Yuan Q., Manhart, C.M., Nguyen B., Kozlov A.K., McHenry S.S., and Lohman T.M. Multiple C-terminal tails within a single E. coli SSB homotetramer coordinate DNA replication and repair. J. Mol. Biol. 2013.

Yupeng Q., Antony E., Doganay S., Koh H.R., Lohman T.M., and Myong S. Srs2 prevents Rad51 filament formation by repetitive motion on DNA. Nature Communications. 2013. 4:2281

Antony E., Kozlov A.J., Nguyen B., and Lohman T.M. Plasmodium falciparum SSB tetramer binds single-stranded DNA only in a fully wrapped mode. J. Mol. Biol. 2012. 420: 284-295. Featured as cover

Antony E., Weiland E.A., Korolev S., and Lohman T.M. Plasmodium falciparum SSB tetramer wraps single-stranded DNA with similar topology but opposite polarity to E. coli SSB. J. Mol. Biol. 2012. 420: 269-283.

Majka A.M., Maluf K.M., Antony E., and Lohman T.M. Self-assembly of E. coli MutL and its complexes with DNA. Biochemistry. 2011.37:7868-80

Antony E., and Lohman T.M. "Non-hexameric SF1 DNA helicases and translocases". Encyclopedia of Biological Chemistry, (2nd edition) W.J. Lennarz and M.D. Lane, eds. Elsevier Science (2010).

Antony E., Tomko E.J., Xiao Q.*, Krejci L., Lohman T.M., and Ellenberger T.E. Srs2 dismantles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA. Molecular Cell. 2009. 35:105-115.
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Antony E., Khubchandani S., Chen S., and Hingorani M.M. Contribution of Msh2 and Msh6 subunits to the asymmetric ATPase and DNA mismatch binding activities of Saccharomyces cerevisiae Msh2-Msh6 mismatch repair protein. DNA Repair. 2006. 5(2):153-62.

Zito C.R. *, Antony E.*, Hunt J.F., Oliver D.B., and Hingorani M.M. Role of a conserved glutamate residue in the Escherichia coli SecA ATPase mechanism. J. Biol. Chem. 2005. 280:14611-14619 (* Co-first authors).

Antony E. and Hingorani M.M. Asymmetric ATP binding and hydrolysis activity of the Thermus aquaticus MutS dimer is key to modulation of its interactions with mismatched DNA. Biochemistry. 2004. 43:13115-13128.

Antony E. and Hingorani M.M. Mismatch recognition-coupled stabilization of Msh2-Msh6 in an ATP-bound state at the initiation of DNA repair. Biochemistry. 2003. 42:7682-93.

Finkelstein J., Antony E., Hingorani M.M., and O'Donnell M. Overproduction and analysis of eukaryotic multiprotein complexes in Escherichia coli using a dual-vector strategy. Anal. Biochem. 2003. 319:78-87.