Antony Laboratory of Structural Enzymology
Department of Biochemistry and Molecular Biology
Saint Louis University School of Medicine
Our Research
We are a team of scientists at the Edward A. Doisy Department of Biochemistry & Molecular Biology at St. Louis University that explore how enzymes function. Enzymes are nature's machines that carry out chemical reactions that sustain life. Our mission is to uncover the molecular & structural principles that govern their mechanisms of action. We dissect how enzymes recognize the correct substrate and function in large assemblies to achieve specific biological tasks. To do so, we apply our expertise in structural biology (x-ray and electron microscopy), ensemble and single-molecule fluorescence (smFRET & optical tweezers), pre-steady state kinetics (stopped and quenched flow), and advanced biophysical methodologies to explore enzyme mechanisms in unprecedented detail.
We investigate enzymes central to the following critical biological processes:
DNA Repair & Recombination
mRNA Recognition and Processing
Long-Range Electron Transfer Oxidoreductases
Why It Matters
Understanding enzyme mechanisms illuminates the foundations of life and informs strategies to combat disease. Our work bridges fundamental biology and translational research, offering pathways to innovation in medicine and biotechnology. Our structural insights help identify therapeutic targets for small-molecule drug development.
We are a team of scientists at the Edward A. Doisy Department of Biochemistry & Molecular Biology at St. Louis University that explore how enzymes function. Enzymes are nature's machines that carry out chemical reactions that sustain life. Our mission is to uncover the molecular & structural principles that govern their mechanisms of action. We dissect how enzymes recognize the correct substrate and function in large assemblies to achieve specific biological tasks. To do so, we apply our expertise in structural biology (x-ray and electron microscopy), ensemble and single-molecule fluorescence (smFRET & optical tweezers), pre-steady state kinetics (stopped and quenched flow), and advanced biophysical methodologies to explore enzyme mechanisms in unprecedented detail.
We investigate enzymes central to the following critical biological processes:
DNA Repair & Recombination
mRNA Recognition and Processing
Long-Range Electron Transfer Oxidoreductases
Why It Matters
Understanding enzyme mechanisms illuminates the foundations of life and informs strategies to combat disease. Our work bridges fundamental biology and translational research, offering pathways to innovation in medicine and biotechnology. Our structural insights help identify therapeutic targets for small-molecule drug development.
We acknowledge funding from the following agencies:
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