Antony Laboratory of Structural Enzymology
Department of Biochemistry and Molecular Biology
Saint Louis University School of Medicine
Our Research
We are a team of scientists in the Edward A. Doisy Department of Biochemistry & Molecular Biology at Saint Louis University, working to uncover how enzymes function at the molecular level. Enzymes are nature’s molecular machines - catalysts that power the chemical reactions essential for life. Our mission is to define the structural and mechanistic principles that govern how these remarkable proteins work.
Our research explores how enzymes recognize substrates with extraordinary specificity, assemble into larger molecular complexes, and coordinate interactions that drive precise biological outcomes. To answer these questions, we integrate a broad suite of state‑of‑the‑art approaches, including:
Our work centers on enzymes critical to fundamental cellular processes, including:
Why It Matters
Understanding enzyme mechanisms reveals the molecular logic that underpins life itself. These insights also guide the development of new strategies to combat human disease. By bridging basic science with translational innovation, our research helps identify new therapeutic targets and informs the design of next‑generation small‑molecule drugs. Ultimately, we aim to translate molecular insights into advances in medicine and biotechnology.
We are a team of scientists in the Edward A. Doisy Department of Biochemistry & Molecular Biology at Saint Louis University, working to uncover how enzymes function at the molecular level. Enzymes are nature’s molecular machines - catalysts that power the chemical reactions essential for life. Our mission is to define the structural and mechanistic principles that govern how these remarkable proteins work.
Our research explores how enzymes recognize substrates with extraordinary specificity, assemble into larger molecular complexes, and coordinate interactions that drive precise biological outcomes. To answer these questions, we integrate a broad suite of state‑of‑the‑art approaches, including:
- Structural biology: X‑ray crystallography and electron microscopy
- Single-molecule and ensemble fluorescence: smFRET and optical tweezers
- Pre–steady-state kinetics: stopped‑flow and quenched‑flow analysis
- Advanced biophysical techniques for probing molecular mechanisms at high resolution
Our work centers on enzymes critical to fundamental cellular processes, including:
- DNA Repair & Recombination
- mRNA Recognition & Processing
- Long‑Range Electron‑Transfer Oxidoreductases
Why It Matters
Understanding enzyme mechanisms reveals the molecular logic that underpins life itself. These insights also guide the development of new strategies to combat human disease. By bridging basic science with translational innovation, our research helps identify new therapeutic targets and informs the design of next‑generation small‑molecule drugs. Ultimately, we aim to translate molecular insights into advances in medicine and biotechnology.
We acknowledge generous funding from the US Taxpayers and following agencies:
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